Effect of vitamin E on lipid peroxidation and liver monooxigenase activity in experimental influenza virus infection.
Identifieur interne : 002D91 ( Main/Exploration ); précédent : 002D90; suivant : 002D92Effect of vitamin E on lipid peroxidation and liver monooxigenase activity in experimental influenza virus infection.
Auteurs : M. Mileva [Bulgarie] ; L. Tancheva ; R. Bakalova ; A. Galabov ; V. Savov ; S. RibarovSource :
- Toxicology letters [ 0378-4274 ] ; 2000.
Descripteurs français
- KwdFr :
- Aminopyrine N-demethylase (antagonistes et inhibiteurs), Aminopyrine N-demethylase (métabolisme), Aniline hydroxylase (antagonistes et inhibiteurs), Aniline hydroxylase (métabolisme), Animaux, Cytochrome P-450 enzyme system (métabolisme), Ethylmorphine-N-demethylase (antagonistes et inhibiteurs), Ethylmorphine-N-demethylase (métabolisme), Foie (), Foie (enzymologie), Foie (virologie), Infections à Orthomyxoviridae (enzymologie), Infections à Orthomyxoviridae (traitement médicamenteux), Inhibiteurs des enzymes du cytochrome P-450, Mâle, Métamizole sodique (métabolisme), NADPH-ferrihemoprotéine reductase (métabolisme), Peroxydation lipidique (), Relation dose-effet des médicaments, Souris, Stress oxydatif (), Substances réactives à l'acide thiobarbiturique (métabolisme), Virus de la grippe A (métabolisme), Vitamine E (pharmacologie).
- MESH :
- antagonistes et inhibiteurs : Aminopyrine N-demethylase, Aniline hydroxylase, Ethylmorphine-N-demethylase.
- enzymologie : Foie, Infections à Orthomyxoviridae.
- métabolisme : Aminopyrine N-demethylase, Aniline hydroxylase, Cytochrome P-450 enzyme system, Ethylmorphine-N-demethylase, Métamizole sodique, NADPH-ferrihemoprotéine reductase, Substances réactives à l'acide thiobarbiturique, Virus de la grippe A.
- pharmacologie : Vitamine E.
- traitement médicamenteux : Infections à Orthomyxoviridae.
- virologie : Foie.
- Animaux, Foie, Inhibiteurs des enzymes du cytochrome P-450, Mâle, Peroxydation lipidique, Relation dose-effet des médicaments, Souris, Stress oxydatif.
English descriptors
- KwdEn :
- Aminopyrine N-Demethylase (antagonists & inhibitors), Aminopyrine N-Demethylase (metabolism), Aniline Hydroxylase (antagonists & inhibitors), Aniline Hydroxylase (metabolism), Animals, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System (metabolism), Dipyrone (metabolism), Dose-Response Relationship, Drug, Ethylmorphine-N-Demethylase (antagonists & inhibitors), Ethylmorphine-N-Demethylase (metabolism), Influenza A virus (metabolism), Lipid Peroxidation (drug effects), Liver (drug effects), Liver (enzymology), Liver (virology), Male, Mice, NADPH-Ferrihemoprotein Reductase (metabolism), Orthomyxoviridae Infections (drug therapy), Orthomyxoviridae Infections (enzymology), Oxidative Stress (drug effects), Thiobarbituric Acid Reactive Substances (metabolism), Vitamin E (pharmacology).
- MESH :
- chemical , antagonists & inhibitors : Aminopyrine N-Demethylase, Aniline Hydroxylase, Ethylmorphine-N-Demethylase.
- chemical , metabolism : Aminopyrine N-Demethylase, Aniline Hydroxylase, Cytochrome P-450 Enzyme System, Dipyrone, Ethylmorphine-N-Demethylase, NADPH-Ferrihemoprotein Reductase, Thiobarbituric Acid Reactive Substances.
- drug effects : Lipid Peroxidation, Liver, Oxidative Stress.
- drug therapy : Orthomyxoviridae Infections.
- enzymology : Liver, Orthomyxoviridae Infections.
- metabolism : Influenza A virus.
- chemical , pharmacology : Vitamin E.
- virology : Liver.
- Animals, Cytochrome P-450 Enzyme Inhibitors, Dose-Response Relationship, Drug, Male, Mice.
Abstract
Influenza virus infection was associated with development of oxidative stress in liver of mice, viz. increase in amount of lipid peroxidation products, decrease in cytochrome P-450 and NADP. H-cytochrome c-reductase activity, and inhibition of liver monooxygenases (aniline hydroxylase, ethylmorphine-N-demethylase, amidopyrine-N-demethylase and analgin-N-demethylase). These effects were most pronounced on the 7th day after virus inoculation as compared to the 5th one. Supplementation of mice with vitamin E before virus inoculation leads to liver protection against oxidative stress and toxicosis. A marked decrease of lipid peroxidation products and an increase of cytochrome P-450 and activities of monooxygenases was established. The stabilizing effect of vitamin E was dose-dependent and was most pronounced on the 5th day after virus inoculation as compared to the 7th one.
DOI: 10.1016/s0378-4274(99)00265-9
PubMed: 10713467
Affiliations:
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Le document en format XML
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Bakalova</name></author><author><name sortKey="Galabov, A" sort="Galabov, A" uniqKey="Galabov A" first="A" last="Galabov">A. Galabov</name></author><author><name sortKey="Savov, V" sort="Savov, V" uniqKey="Savov V" first="V" last="Savov">V. Savov</name></author><author><name sortKey="Ribarov, S" sort="Ribarov, S" uniqKey="Ribarov S" first="S" last="Ribarov">S. 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Mileva</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Physics and Biophysics, Medical University, 2 Zdrave Str., Sofia, Bulgaria.</nlm:affiliation><country xml:lang="fr">Bulgarie</country><wicri:regionArea>Department of Medical Physics and Biophysics, Medical University, 2 Zdrave Str., Sofia</wicri:regionArea><placeName><settlement type="city">Sofia</settlement><region nuts="2">Sofia-ville (oblast)</region></placeName></affiliation></author><author><name sortKey="Tancheva, L" sort="Tancheva, L" uniqKey="Tancheva L" first="L" last="Tancheva">L. Tancheva</name></author><author><name sortKey="Bakalova, R" sort="Bakalova, R" uniqKey="Bakalova R" first="R" last="Bakalova">R. Bakalova</name></author><author><name sortKey="Galabov, A" sort="Galabov, A" uniqKey="Galabov A" first="A" last="Galabov">A. Galabov</name></author><author><name sortKey="Savov, V" sort="Savov, V" uniqKey="Savov V" first="V" last="Savov">V. Savov</name></author><author><name sortKey="Ribarov, S" sort="Ribarov, S" uniqKey="Ribarov S" first="S" last="Ribarov">S. Ribarov</name></author></analytic><series><title level="j">Toxicology letters</title><idno type="ISSN">0378-4274</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aminopyrine N-Demethylase (antagonists & inhibitors)</term><term>Aminopyrine N-Demethylase (metabolism)</term><term>Aniline Hydroxylase (antagonists & inhibitors)</term><term>Aniline Hydroxylase (metabolism)</term><term>Animals</term><term>Cytochrome P-450 Enzyme Inhibitors</term><term>Cytochrome P-450 Enzyme System (metabolism)</term><term>Dipyrone (metabolism)</term><term>Dose-Response Relationship, Drug</term><term>Ethylmorphine-N-Demethylase (antagonists & inhibitors)</term><term>Ethylmorphine-N-Demethylase (metabolism)</term><term>Influenza A virus (metabolism)</term><term>Lipid Peroxidation (drug effects)</term><term>Liver (drug effects)</term><term>Liver (enzymology)</term><term>Liver (virology)</term><term>Male</term><term>Mice</term><term>NADPH-Ferrihemoprotein Reductase (metabolism)</term><term>Orthomyxoviridae Infections (drug therapy)</term><term>Orthomyxoviridae Infections (enzymology)</term><term>Oxidative Stress (drug effects)</term><term>Thiobarbituric Acid Reactive Substances (metabolism)</term><term>Vitamin E (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Aminopyrine N-demethylase (antagonistes et inhibiteurs)</term><term>Aminopyrine N-demethylase (métabolisme)</term><term>Aniline hydroxylase (antagonistes et inhibiteurs)</term><term>Aniline hydroxylase (métabolisme)</term><term>Animaux</term><term>Cytochrome P-450 enzyme system (métabolisme)</term><term>Ethylmorphine-N-demethylase (antagonistes et inhibiteurs)</term><term>Ethylmorphine-N-demethylase (métabolisme)</term><term>Foie ()</term><term>Foie (enzymologie)</term><term>Foie (virologie)</term><term>Infections à Orthomyxoviridae (enzymologie)</term><term>Infections à Orthomyxoviridae (traitement médicamenteux)</term><term>Inhibiteurs des enzymes du cytochrome P-450</term><term>Mâle</term><term>Métamizole sodique (métabolisme)</term><term>NADPH-ferrihemoprotéine reductase (métabolisme)</term><term>Peroxydation lipidique ()</term><term>Relation dose-effet des médicaments</term><term>Souris</term><term>Stress oxydatif ()</term><term>Substances réactives à l'acide thiobarbiturique (métabolisme)</term><term>Virus de la grippe A (métabolisme)</term><term>Vitamine E (pharmacologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Aminopyrine N-Demethylase</term><term>Aniline Hydroxylase</term><term>Ethylmorphine-N-Demethylase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Aminopyrine N-Demethylase</term><term>Aniline Hydroxylase</term><term>Cytochrome P-450 Enzyme System</term><term>Dipyrone</term><term>Ethylmorphine-N-Demethylase</term><term>NADPH-Ferrihemoprotein Reductase</term><term>Thiobarbituric Acid Reactive Substances</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Aminopyrine N-demethylase</term><term>Aniline hydroxylase</term><term>Ethylmorphine-N-demethylase</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Lipid Peroxidation</term><term>Liver</term><term>Oxidative Stress</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Foie</term><term>Infections à Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Liver</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Aminopyrine N-demethylase</term><term>Aniline hydroxylase</term><term>Cytochrome P-450 enzyme system</term><term>Ethylmorphine-N-demethylase</term><term>Métamizole sodique</term><term>NADPH-ferrihemoprotéine reductase</term><term>Substances réactives à l'acide thiobarbiturique</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Vitamine E</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Vitamin E</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Foie</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Liver</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cytochrome P-450 Enzyme Inhibitors</term><term>Dose-Response Relationship, Drug</term><term>Male</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Foie</term><term>Inhibiteurs des enzymes du cytochrome P-450</term><term>Mâle</term><term>Peroxydation lipidique</term><term>Relation dose-effet des médicaments</term><term>Souris</term><term>Stress oxydatif</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Influenza virus infection was associated with development of oxidative stress in liver of mice, viz. increase in amount of lipid peroxidation products, decrease in cytochrome P-450 and NADP. H-cytochrome c-reductase activity, and inhibition of liver monooxygenases (aniline hydroxylase, ethylmorphine-N-demethylase, amidopyrine-N-demethylase and analgin-N-demethylase). These effects were most pronounced on the 7th day after virus inoculation as compared to the 5th one. Supplementation of mice with vitamin E before virus inoculation leads to liver protection against oxidative stress and toxicosis. A marked decrease of lipid peroxidation products and an increase of cytochrome P-450 and activities of monooxygenases was established. The stabilizing effect of vitamin E was dose-dependent and was most pronounced on the 5th day after virus inoculation as compared to the 7th one.</div></front></TEI><affiliations><list><country><li>Bulgarie</li></country><region><li>Sofia-ville (oblast)</li></region><settlement><li>Sofia</li></settlement></list><tree><noCountry><name sortKey="Bakalova, R" sort="Bakalova, R" uniqKey="Bakalova R" first="R" last="Bakalova">R. Bakalova</name><name sortKey="Galabov, A" sort="Galabov, A" uniqKey="Galabov A" first="A" last="Galabov">A. Galabov</name><name sortKey="Ribarov, S" sort="Ribarov, S" uniqKey="Ribarov S" first="S" last="Ribarov">S. Ribarov</name><name sortKey="Savov, V" sort="Savov, V" uniqKey="Savov V" first="V" last="Savov">V. Savov</name><name sortKey="Tancheva, L" sort="Tancheva, L" uniqKey="Tancheva L" first="L" last="Tancheva">L. Tancheva</name></noCountry><country name="Bulgarie"><region name="Sofia-ville (oblast)"><name sortKey="Mileva, M" sort="Mileva, M" uniqKey="Mileva M" first="M" last="Mileva">M. Mileva</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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